Faculty Practice · Mount Sinai Health System · Upper East Side, NYC
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Alfred Iloreta, MD Director · Endoscopic Skull Base Surgery
Research · Outcomes

Measuring what matters.

Does the endoscopic approach actually deliver better outcomes than opening the skull? The group's decade-long institutional series, national database analyses, and systematic reviews put numbers behind the answer — and extend outcomes research into survivorship, including mental health after a skull base diagnosis.

Why it matters

Ten years of institutional evidence.

Mount Sinai's skull base program has published its own report card: a ten-year comparison of endoscopic versus transcranial approaches for skull base malignancies and an eight-year technological analysis of advanced endoscopic resection. The group also led a systematic review of exclusively endoscopic resection for esthesioneuroblastoma and contributed to the International Consensus Statement on sinonasal tumors — the field's reference document.

Outcomes research here extends past survival curves: a 2025 national analysis identified risk factors for suicidal ideation in patients with skull base tumors — turning survivorship and mental health into measurable, treatable parts of care.

Key publications

Selected papers.

  • Surgical outcomes in patients with endoscopic versus transcranial approach for skull base malignancies: a 10-year institutional experience. British Journal of Neurosurgery, 2020. PubMed
  • The Role of Advanced Endoscopic Resection of Diverse Skull Base Malignancies: Technological Analysis during an 8-Year Single Institutional Experience. Journal of Neurological Surgery Part B, 2020. PubMed
  • Exclusively endoscopic surgical resection of esthesioneuroblastoma: A systematic review. World Journal of Otorhinolaryngology — Head and Neck Surgery, 2022. PubMed
  • International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors. International Forum of Allergy & Rhinology, 2024. PubMed · DOI
  • Risk Factors for Suicidal Ideation and Attempt in Patients With Skull Base Tumors. Otolaryngology–Head and Neck Surgery, 2025. PubMed · DOI
  • Predictors of Prolonged Length of Stay After Pituitary Adenoma Resection: A Large Cohort Analysis Using the National Inpatient Sample. American Journal of Rhinology & Allergy, 2023. PubMed
In practice

Why this matters for your case.

This evidence base directly shapes how pituitary and skull base surgery is offered: which tumors are approached endoscopically, what patients are told to expect, and how follow-up is structured.

Questions about this research — or a case it could help? Reach out.

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