Faculty Practice · Mount Sinai Health System · Upper East Side, NYC
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Alfred Iloreta, MD Director · Endoscopic Skull Base Surgery
Research · Olfaction

The science of getting smell back.

When COVID-19 made anosmia a household word, this group was already studying the olfactory system. Its work spans a clinical trial of omega-3 supplementation for persistent COVID-related smell loss, characterization of parosmia, and long-term data on how smell recovers after sinus surgery.

Why it matters

Smell loss is not trivial.

Smell is tied to taste, memory, safety, and mood — and losing it is consistently rated among the most distressing chronic symptoms patients report. The research program treats olfaction as a system that can be measured, protected during surgery, and actively rehabilitated.

The omega-3 supplementation trial for persistent COVID-related olfactory dysfunction tested an accessible intervention for a condition with few options; the parosmia work characterized the distorted-smell syndrome that follows viral injury; and long-term outcome studies after frontal sinus surgery quantified how much olfaction CRS patients actually regain.

Key publications

Selected papers.

  • Omega-3 Fatty Acid Supplementation for the Treatment of Persistent COVID-Related Olfactory Dysfunction. American Journal of Rhinology & Allergy, 2023. PubMed
  • Clinical Features of Parosmia Associated With COVID-19 Infection. The Laryngoscope, 2021. PubMed
  • Long Term Olfactory Outcomes Following Frontal Sinus Surgery in Chronic Rhinosinusitis. The Laryngoscope, 2021. PubMed
In practice

If you've lost your smell.

The clinical side of this program lives on the loss of smell page — workup, treatment, and what research participation can offer when standard options are exhausted.

Questions about this research — or a case it could help? Reach out.

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